Margaret Brimble

Margaret Brimble, Professor of University of Auckland, Auckland, New Zealand. General Interests: Synthesis of bioactive natural products especially natural products from extreme environments eg shellfish toxins and polyketides from metal-laden lakes. Synthesis of anti-H.Pylori agents and antibacterial agents. Synthesis of antimicrobial peptides and cell penetrating peptides. Synthesis of (glyco)peptides as components for cancer vaccines. Use of click chemistry to prepare neoglycopeptides, neophosphopeptides and neolipopeptides.Synthesis of rhinovirus 3C protease inhibitors as antiviral agents. Synthesis of pyranonaphthoquinone antibiotics as bioreductive alkylating anticancer agents. Synthesis of topoisomerase inhibitors and telomerase inhibitors. Synthesis of peptidomimetics as neuroprotective agents. Synthesis of fish antifreeze peptides. Synthesis of Advanced Glycation End-products (AGEs) and their implication on the onset of cardiovascular disease and diabetes. Synthesis of insect antifeedants, insect pheromones and insecticides. Synthesis of manuka honey components. Synthesis of glycopolymers and bone promoting peptide scaffolds as new biomaterials. Synthesis of rat selective toxicants including CO releasing molecules (CORMs). Synthesis of pro-drugs of antibiotics to treat bovine mastitis. Synthesis of novel organocatalysts.