李霞

李　霞，博士、研究员，博士生导师 1985-1995年在河北师范大学生物系获得理学学士和植物生理学硕士学位，并留校任讲师。1995-2001在美国Purdue University生物系和园艺系工作和学习，获得博士学位。2001-2004年在美国Vector Tobacco公司任科学家和课题组长。2004年入选中国科学院“百人计划”，回遗传与发育生物学研究所石家庄农业资源研究中心工作。 研究方向 1、植物抗逆分子机制的研究 植物对逆境响应以及抗逆的分子机制是一个重要的生物学问题，涉及到植物在逆境下的可塑性发育、基础代谢以及植物细胞、组织和个体得能量、水分、离子、氧化还原物的稳态的调控等生物学过程。本课题组的研究方向是高等植物逆境生理和分子遗传学。主要包括模式植物拟南芥、小麦和大豆在非生物逆境尤其抗盐碱、干旱和低温条件下的生理和遗传机理。重点是植物根系发育对逆境适应和调控分子网络，逆境条件下植物防御代谢的转换的机制，以及植物生理节水的遗传学基础。最终目标是揭示植物抗逆的分子机理，用遗传转化手段创建抗盐碱和抗旱节水新作物品系。 2、大豆固氮效率调控机理的研究 大豆是重要的经济作物，是植物蛋白和油脂的主要来源。大豆可以和根瘤菌共生形成根瘤，进而把空气中的N2转化为植物可以利用的NH3。大豆根瘤的发育和固氮效率的高低是影响大豆高产优质的关键因素，二者对环境胁迫非常的敏感。本课题组利用反向遗传学以及转基因等方法对大豆根瘤发育和固氮效率对非生物胁迫响应的分子机制进行系统性研究。重点研究大豆miRNA及靶基因影响大豆根瘤发育和固氮效率的分子调控网络。 发表文章（* 通讯作者） Wang Y, Li K, Chen L, Zou Y, Liu H, Tian Y, Li D, Wang R, Zhao F, Ferguson B, Gresshoff P, Li X*. (2015) MicroRNA167-directed regulation of the auxin response factors, GmARF8a and GmARF8b, is required for soybean (Glycine max L.) nodulation and lateral root development. Plant Physiology DOI:10.1104/pp.15.00265. Wang Y, Wang L, Zou Y, Chen L, Cai Z, Zhang S, Zhao F, Tian Y, Jiang Q, Ferguson B, Gresshoff P, Li X*. (2014) Soybean miR172c targets the repressive AP2 transcription factor NNC1 to activate ENOD40 expression and regulate nodule initiation. Plant Cell 26: 4782-4801. Ji H, Wang S, Li K, Szakonyi D, Koncz C, Li X*. (2014) PRL1 modulates root stem cell niche activity and meristem size through WOX5 and PLTs in Arabidopsis. Plant Journal 81: 399-412. Ji H, Liu L, Li K, Xie Q, Wang Z, Zhao X, Li X*. (2014) PEG-mediated osmotic stress induces premature differentiation of the root apical meristem and outgrowth of lateral roots in wheat. Journal of Experimental Botany 65: 4863-4872. Kong D, Li M, Dong Z, Ji H, Li X*. (2014) Identification of TaWD40D, a wheat WD40 repeat-containing protein that is associated with plant tolerance to abiotic stresses. Plant Cell Report 34: 395-410. Zhang S, Wang Y, Li K, Zou Y, Chen L, Li D, Cai Z, Wang L, Wang R, Wang Y, Li X*. (2014) Uncovering miRNA-mediated responses to low temperature in nitrogen-fixing nodules of soybean. International Journal of Molecular Sciences 15: 13596-13614. Liu L, Guo G, Wang Z, Ji H, Mou F, Li X*. (2014) Auxin in plant growth and stress responses. In: Lam-Son Phan Tran and Sikander Pal (eds). Phytohormones: A window to metabolism, signaling and biotechnological application. Springer Science, New York, USA, pp1-35. Li D, Liu H, Qiao Y, Wang Y, Cai Z, Dong B, Shi C, Liu Y, Li X, Liu Mengyu. (2013) Effects of elevated CO2 on the growth, seed yield, and water use efficiency of soybean (Glycine max (L.) Merr.) under drought stress. Agricultural Water Management 129: 105-112. Zou Y, Wang Y, Wang L, Yang L, Wang R, Li X*. (2013) miR172b controls the transition to autotrophic development inhibited by ABA in Arabidopsis. PLoS ONE 23: e64770. Luo Y, Wang Z, Ji H, Fang H, Wang S, Tian L, Li X*. (2013) An Arabidopsis homolog of importin beta 1 is required for ABA response and drought tolerance. Plant Journal 75: 377-389. Dong Z, Shi L, Wang Y, Chen L, Cai Z, Wang Y, Jin J, Li X*. (2013) Identification and dynamic regulation of microRNAs involved in salt stress responses in functional soybean nodules by high-throughput sequencing. International Journal of Molecular Sciences 14: 2717-2738. Peng Y, Ma W, Chen L, Yang L, Li S, Zhao H, Zhao Y, Jin W, Li N, Bevan MW, Li X, Tong Y, Li Y. (2013) Control of root meristem size by DA1-related protein 2 in Arabidopsis thaliana. Plant Physiology 16: 1542-1556. Zhao H, Liu L, Mo H, Qian L, Cui S, Li X, Ma L. (2013) The ATP-binding cassette transporter ABCB19 regulates postembryonic organ separation in Arabidopsis. PLoS ONE 8: e60809. Ji H, Pardo JM, Batelli G, Van Oosten MJ, Bressan RA, Li X*. (2013) The salt overly sensitive (SOS) pathway: established and emerging roles. Molecular Plant 6: 275-286. Zhao H, Wang X, Zhu D, Cui S, Li X, Cao Y, Ma L. (2012) A single amino acid substitution in IIIf subfamily of basic Helix-Loop-Helix transcription factor AtMYC1 leads to trichome and root hair patterning defects by abolishing its interaction with partner proteins in Arabidopsis. Journal of Biological Chemistry 287: 14109-14121. Hao L, Wang W, Chen C, Wang Y, Liu T, Li X, Shang Z. (2012) Extracellular ATP promotes stomatal opening of Arabidopsis thaliana through heterotrimeric G protein a subunit and reactive oxygen species. Molecular Plant 5: 852-864. Zhao Y, Wang T, Zhang W, Li X*. (2011) SOS3 mediates lateral root development under low salt stress through regulation of auxin redistribution and maxima in Arabidopsis. New Phytologist 189: 1122-1134. Cao M, Li X*. (2010) Die for living better: Plants modify root system architecture through inducing PCD in root meristem under severe water stress. Plant Signaling & Behavior 5: 1-2. Orsini F, D'Urzo MP, Inan G, Serra S, Oh DH, Mickelbart MV, Consiglio F, Li X, Jeong JC, Yun DJ, Bohnert HJ, Bressan RA, Maggio A. (2010) A comparative study of salt tolerance parameters in 11 wild relatives of Arabidopsis thaliana. Journal of Experimental Botany 61: 3787–3798. Zhao Y, Wang T, Zhang W, Li X*. (2010) The role of auxin in plastic development of plant root system architecture in response to abiotic stimuli. Plant Nutrition and Abiotic Stress Tolerance. Global Science Books. Isleworth, UK, pp19-32. Zhao Y, Wang T, Zhang W, Li X*. (2010) SOS3 mediates lateral root development under low salt stress through regulation of auxin redistribution and maxima in Arabidopsis. New Phytologist 189: 1122-1134. Duan Y, Zhang W, Li B, Wang Y, Li K, Sodmergen, Han C, Li X*. (2010) An ER response pathway mediates programmed cell death of root tip induced by water stress in Arabidopsis. New Phytologist 186: 681-95. Xu J, Yin H, Liu X, Li X*. (2010) Salt affects plant Cd-stress responses by modulating growth and Cd accumulation. Planta 231: 449-59. Xie Q, Yan X, Liao X, Li X*. (2009) The arsenic hyperaccumulator fern Pteris vittata L. Environmental Science & Technology 43: 8488-8495. Xu J, Yin H, Li X*. (2009) Protective effects of proline against cadmium toxicity in micropropagated hyperaccumulator, Solanum nigrum L. Plant Cell Reports 28: 325-33. Wang Z, Li X*. (2009) IAN/GIMAPs are conserved and novel regulators in vertebrates and angiosperm plants. Plant Signaling & Behavior 4: 1-3. Wang Y, Li K, Li X*. (2009) Auxin redistribution modulates plastic development of root system architecture under salt stress in Arabidopsis thaliana. Journal of Plant Physiology 166:1637-1645. Wang Y, Li P, Cao X, Wang X, Zhang A, Li X*. (2009) Identification and expression analysis of miRNAs from nitrogen-fixing soybean nodules. Biochemical and Biophysical Research Communications 378: 799-803. Quist T, Sokolchik I, Shi H, Joly R, Bressan R, Maggio A, Narsimhan M, Li X*. (2009) HOS3, an ELO-Like gene, inhibits effects of ABA and implicates a S-1-P/Ceramide control system for abiotic stress responses in Arabidopsis thaliana. Molecular Plant 2: 138-151. Xu J, Yin H, Wang W, Mi Q, Liao X, Li X*. (2009) Identification of Cd-responsive genes of solanum nigrum seedlings through differential display. Plant Molecular Biology Reporter 27: 563-569. Wang X, Gao Z, Wang Y, Bressan RA, Weller SC, Li X*. (2009) Highly efficient in vitro adventitious shoot regeneration of peppermint (Mentha x piperita L.) using internodal explants. In Vitro Cellular & Developmental Biology- Plant 45: 435-440. Manabe Y, Bressan R, Wang T, Li F, Koiwa H, Sokolchik I, Li X*, Maggio A*. (2008) The Arabidopsis kinase-associated protein phosphatase regulates adaptation to Na+ stress. Plant Physiology 146: 612-622. Sun F, Zhang W, Hu H, Li B, Wang Y, Zhao Y, Liu M, Li X*. (2008) Salt modulates gravity signaling pathway to regulate growth direction of primary roots in Arabidopsis thaliana. Plant Physiology 146:178-88. Wang Y, Zhang W, Li K, Sun F, Han C, Wang Y, Li X*. (2008) Salt-induced plasticity of root hair development is caused by ion disequilibrium in Arabidopsis thaliana. Journal of Plant Research 121: 87-98. Wang Y, Li X*. (2008) Salt stress-induced cell reprogramming cell fate switch and adaptive plasticity during root hair development in Arabidopsis. Plant Signaling & Behavior 3: 436 -438. Li X*, Zhang W. (2008) Salt-avoidance tropism in Arabidopsis. Plant Signaling & Behavior 3: 351-353. Liu C, Wang T, Zhang W, Li X*. (2008) Computational identification and analysis of immune-associated nucleotide gene family in Arabidopsis thaliana. Journal of Plant Physiology 165: 777-787. Wang Y, Wang T, Li K, Li X*. (2008) Genetic analysis of involvement of ETR1 in plant response to salt and osmotic stress. Plant Growth Regulation 54: 261-269. Li K, Wang Y, Han C, Zhang W, H Jia, Li X*. (2007) GA signaling and CO/FT regulatory module mediate salt-induced late flowering in Arabidopsis thaliana. Plant Growth Regulation 53: 195-206. Inan G, Goto F, Jin J, A Rosado, Koiwa H, Shi H, Hasegawa PM, Bressan RA, Maggio A, Li X*. (2007) Isolation and characterization of shs1, a sugar-hypersensitive and ABA-insensitive mutant with multiple stress responses. Plant Molecular Biology 65: 295-309. Wang Y, C Liu, K Li, F Sun, H Hu, Li X*. (2007) Arabidopsis EIN2 modulates stress response through abscisic acid response pathway. Plant Molecular Biology 64: 633-644. Zhang W, Li X, Liu JB. (2007) Genetic variation of Bmy1 alleles in barley (Hordeum vulgare L.) investigated by CAPS analysis. Theoretical Applied Genetics 114: 1039-1050.