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会议详情 |
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2014-10-29 00:00 至 2014-10-30 00:00
推荐会议：2025中国医疗行业CIO大会暨首届中国医疗AI大模型应用大会
发票类型：增值税普通发票 增值税专用发票
Primary hepatocytes derived from liver organs have brought sentimental contribution to fundamental liver biology research and in various pharmaceutical and clinical applications such as drug metabolism and toxicity, and virology. Specifically, human primary hepatocytes are regarded as “Gold Standard” for ADMET evaluation by FDA in drug development. Furthermore, latest advances have demonstrated hepatocytes transplantation as a promising approach for treatment of acute and chronic liver failure. However, the demand for liver organs and functional hepatocytes far exceeds the supply of cadaveric livers and liver tissues from living donors. Hence, generation of functional and expandable hepatocytes is the key to meet these demands.
Great efforts have been made to obtain surrogate human functional hepatocytes, such as derivation of HepaRG cell line and differentiation of embryonic stem cells (ESC) or induced pluripotent stem cells (iPSC) to hepatocyte-like cells. A remarkable advance lately is the direct conversion of fibroblasts to functional hepatocyte-like cells. However, despite the great potential of these new technologies to obtain hepatocyte-like cells, little progresses have been made to push their applications forward to clinics or industries.
For this reason, we would like to propose this symposium to bring academia, industry and clinic together and update the latest achievements about the obtainment and application of hepatocyte-like cells. Our goals include integrating latest technical progresses, bridging the demands from clinic and industry, and leading to solutions of some urgent problems in these areas. We hope that in the near future functional hepatocytes will be used and lead to remarkable advances in various fields, including cell-based therapies, bio-artificial liver devices and mechanistic evaluation of hepatotoxicity and metabolism of new drug candidates.
WEDNESDAY, Oct 29th MORNING
SESSION 1 Generation of Functional Hepatocytes
Latest progresses of various novel technologies to generate functional hepatocytes will be reported. Advantages and drawbacks of each technology will be discussed in this session.
David Hay Ph.D.
University of Edinburgh, UK
André Guillouzo Ph.D.
Inserm U991, France
Lijian Hui Ph.D.
Shanghai Institute of Biochemistry and Cellular Biology, China
Xin Wang Ph.D.
Inner Mongolia University, China
Andreas Nüssler Ph.D.
Eberhard Karls University, Tübingen, Germany
Knut R. Steffensen Ph.D.
Karolinska Institutet, Sweden
WEDNESDAY, Oct 29th AFTERNOON
SESSION 2 Industrial Applications of Functional Hepatocytes
Applications in drug metabolism, drug toxicology, in vitro models of hepatitis viruses and humanized animals will be discussed.
Kim Brouwer Pharm.D., Ph.D.
University of North Carolina at Chapel Hill, USA
Guoyu Pan Ph.D.
Shanghai Institute of Materia Medica, China
Ji Y. (Jeff) Zhang Ph.D.
Novartis, China
Albert P. Li Ph.D.
In Vitro ADMET Laboratories, LLC, USA
Wenhui Li Ph.D.
National Institute of Biological Sciences, China
Lishan Su Ph.D.
University of North Carolina at Chapel Hill, USA
THURSDAY, Oct 30th MORNING
SESSION 3 Industrial Applications of Functional Hepatocytes
Potential applications in clinics, including applications for cell transplantation and bio-artificial liver device.
Stephen Strom Ph.D.
Karolinska Institutet, Sweden
Anil Dhawan Ph.D.
King's College London, UK
Ewa Ellis Ph.D.
Karolinska Institutet, Sweden
Roberto Gramignoli Ph.D.
Karolinska University Hospital, Sweden
THURSDAY, Oct 30th AFTERNOON
SESSION 4 Future Technologies
Potential applications in clinics, including applications for cell transplantation and bio-artificial liver device.
Wei-Shuo Hu Ph.D.
University of Minnesota, US
Robert A.F.M. Chamuleau M.D., Ph.D.
University of Amsterdam, Netherlands
Scott Nyberg M.D.
Mayo Clinic College of Medicine, Rochester, Minnesota, USA
Takanori Takebe M.D.
Yokohama City University, Japan
Andrew Wan Ph.D.
Institute of Bioengineering and Nanotechnology, Singapore
Alejandro Soto-Gutiérrez M.D., Ph.D.
University of Pittsburgh, US
8月31日前报名：人民币1600元，美元320
8月31日后报名：人民币2000元，美元400
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