2017第十五届国际新药发明科技年会

论坛 1：细胞分子水平的药物发现

题目: Sanfilippo B Syndrome: CRISPR-Cas9 Correction of Naglu Gene Mutations in Induced Pluripotent Stem Cellsderived from Skin Fibroblasts of Patients

Francis Choy博士，加拿大维多利亚大学教授

题目: Novel Mutations in Quinolone Resistance-Determining Regions of gyrA, gyrB, parC and parE in Shigella Flexneri Clinical Isolates from Eastern Chinese Populations Between 2001 and 2015

Bing Gu博士，徐州医科大学的附属医院实验室医学系副主任

题目: rLj-RGD3 Induces Apoptosis via the Mitochondrial-dependent Pathway and Inhibits Adhesion, Migration and Invasion of Human HeyA8 Cells via FAK Pathway

Rong Xiao博士，辽宁师范大学生命科学学院副教授

题目: Deciphering Single Cell Metabolism by Coherent Raman Scattering Microscopy

Shuhua Yue博士，北京航空航天大学生物科学与医学工程学院副教授

题目: Epigenetic Regulation on Sonic Hedgehog Signaling Pathway in NTDs

Li Wang博士，首都儿科研究所副研究员

 

论坛2：基础科学中的药物发现

题目：Neuroreceptors and Neurotransmitters: Latest Frontiers for Psychotropic Drug Development

Rakesh Ranjan博士，美国Charak临床研究中心执行医学主任

题目：The Lack of Raf-1 Kinase Feedback Regulation Enhances Anti-apoptosis in Cancer Cells
Changmin Chen博士，中国四川肿瘤医院基础研究系主任

题目：Effects and Mechanisms of Cold-induced Rat White/Brown Adipose Tissue Changes on Plasticity and Metabolism by SiO2 Nanoparticles
Danfeng Yang博士，中国天津卫生与环境医学研究所教授

 

论坛3：药理学，毒理学，病理学水平的药物发现

题目：Integrating New Technologies - MST and NanoDSF in the Modern Drug Discovery Workflow
Alexey Rak博士，法国赛诺菲研发生物结构和生物物理学主任

题目：Evaluation of Heavy-chain C-terminal Deletion on Product Quality and Pharmacokinetics of Monoclonal Antibodies

Guoying Jiang 博士，美国基因工程技术公司分析开发和质量控制高级科学家和组长

题目：Rolapitant Absolute Bioavailability and PET Imaging Studies in Healthy Adult Volunteers
Xiaodong Wang博士，美国Tesaro公司高级主管

题目：Immunotoxicity Testing of Nano-drugs, Biologicals and Development of Safe Application of Them
Rudolf Urbanics博士，匈牙利SeroScience有限公司Vivo实验室负责人

题目：Interactions of Glutamate and IGF-1 Receptor Signaling and Its Underlying Mechanisms
Wenhua Zheng博士，中国澳门大学健康科学学院教授

题目：New Use of Old Drug: Introduction of the Rapid Antidepressant Effects of Ketamine and the Underlying Mechanism
Jianjun Yang博士，中国东南大学医学院中大医院麻醉科教授

题目：T-patterns and Self-similarity from DNA to Neuronal and Human Scales
Magnus S. Magnusson博士，冰岛大学研究教授

题目：Induction Chemotherapy Followed by Concurrent Radio-chemotherapy Versus Concurrent Radio-chemotherapy Alone as Treatment of Locally Advanced Squamous Cell Carcinoma of the Head and Neck (HNSCC): A Meta-analysis of Randomized Trials

Edwin Bolke博士，德国海因里希海恩大学放射肿瘤学系教授

题目： New Aspects Regarding Neoadjuvant Radiochemotherapy in Locally Advanced Noninflammatory Breast Cancer and Predictive Factors for a Pathologic Complete Remission
Christiane Matuschek博士，德国海因里希·海恩大学高级主任医师

 

论坛4：药物发现技术

题目: ALIS Affinity Selection in Pharmaceutical Discovery

Peter J. Dandliker博士，美国默克公司经理

题目: Understanding Grinding Stress in Monoclonal Antibody Drug Production Manufacturing Process - Application of QbD Approach

Yuh-Fun Maa博士，美国基因技术公司高级首席工程师

题目: Lanthanide Helicates for Optical Bioimaging and Theranostics

Jean-Claude G. Bunzli博士，香港浸会大学、瑞士联邦理工学院教授

题目:Semiempirical Quantum Mechanics (SQM)-based Scoring Functions for Native Protein-Ligand Pose Recognition and Virtual Screening

Pavel Hobza博士，有机化学和生物化学研究所

题目: Zebrafish: A Predictive Model for Drug Discovery and Reprofiling

Yong Zhang博士，中国猎人生物技术有限公司总裁助理和营销总监

题目: Double Strand DNA Recognition by Peptides Consisting of Pyrrole and Imidazole Moiety for Diagnosticprobes and/or Gene Control Drugs

Kiyoshi Nokihara博士，日本制药公司首席执行官；南京医科大学教授

题目: New Tools for Drug Target Identification and Prioritization

Alexey Dubovenko先生，美国Clarivate分析发现科学的解决方案产品经理

 

论坛 5：新生物治疗与生物药发现

题目：An Easy-to-Use, Sterile, High-Speed Cell Sorter for Clinical Production of Therapeutic Cells

John S. Foster博士，美国Owl生物医学董事长

题目：Intestinal Tract as Bioreactor for Therapeutic Proteins Production Baised on a Fructose Inducible Expression System of Lactic Acid Bacteria
Weisen Zeng博士，中国南方医科大学教授

题目：Rapidly Effective IVIG Therapy Has Corticosteroid-Sparing and Immunomodulatory Effects in Autoimmune Bullous Disease Pemphigus Vulgaris
Danka Svecova博士，斯洛伐克共和国夸美纽斯大学教授

题目：Establishment and Therapeutic Application of Universal hESC Lines
Geeta Shroff博士，印度Nutech Mediworld公司的创始人兼医疗总监

题目： Oral Administration of Chitosan/DNA Nanoparticles Containing DNA Coding for FVIII and IL-10 for the Modulation of Antibody Responses to FVIII in Hemophilia Mice
Gonzalo Hortelano博士，哈萨克斯坦共和国纳扎尔巴耶夫大学生物学院生物学教授

题目：Optimizing the Property of Nano-hydroxyapatite Gene Vectors with Variety of Surface-modification
Fengjun Wang博士，中国中南大学博士湘雅医院医生

 

论坛6：天然产物和中医

专场一: 活性天然产物的合成和分离

题目: Identification, Quantitation and Bioavailability of Calcium Fructo-borate Natural Complex Using Multinuclear NMR and LC-MS(n)

Boris V. Nemzer博士，美国伊利诺伊大学香槟分校副教授，FutureCeuticals公司高级研发主任

题目: Antibacterial Agents from Chinese Medicinal Plants

Weidong Pan博士，中国科学院贵州省自然产品化学重点实验室教授

题目: Novel Triptolide-related Compounds as Potential Anticancer and Antivirus Clinical Trial Candidates

Jinghong Zhang博士，华侨大学生物医学学院教授

题目: Preliminary Study on Analgesic Mechanism of Three Components of Dragon’s Blood

Xiangming Liu博士，中南民族大学教授

题目: New Coumarins from Aerial Parts of Ammi majus L and Their Cytotoxic Activity

Eman Elsharkawy博士，埃及北方边境大学副教授

 

专场二：天然产物的生物活性

题目: Tocotrienols from Red Palm Oil; An Important New Supplement for Aging Populations

Joseph Keenan博士，美国明尼苏达大学家庭医学部教授

题目: A New Way of Drug R & D - Methodology of Reverse Pharmacology

Jun Li博士，中南民族大学药学院副院长

题目: Screening and Application of Active Compounds Targeting on Tyrosine Kinase Receptors

Yanmin Zhang博士，西安交通大学药学院教授

题目: 5-hydroxy-equol, A Microbial Metabolite of Isoflavone Genistein, Enhanced Lifespan and Stress Resistance inCaenorhabditis Elegans

Xiuling Wang博士，河北农业大学教授

题目: Artemisinin Protected Various Cell Types from Oxidative Stress Injury and Its Underlying Mechanism

Wenhua Zheng博士，澳门大学健康科学学院教授

 

论坛7：药物递送的挑战与对策

题目: Oral Delivery Using Nanoparticles

Deepak Hegde博士，葛兰素史克上海研发公司产品开发部主任

题目: IVIVC/IVIVR Development in the Pharmaceutical Industry – Past Experience and Current Perspectives

Rong Li博士，美国辉瑞公司医药研发部副研究员

题目: The HFA Challenge! The Canister Role as an Integral Part of the pMDI Drug Delivery System

Anselm Ebert博士，德国普莱斯帕商务部主任

题目: Multipurpose Prevention Technologies: What Does the Future Hold?

David R. Friend博士，美国Evofern生物科学公司首席科学家

 

论坛 8：实践与药物创新

专场一：新抗癌药物

题目: Substituted and Fused 7-deazapurine Nucleosides – New Type of Potent Cytostatics with a Complex Mechanism of Action

Michal Hocek博士，捷克科学院有机化学与生物化学研究所教授

题目: Targeted Therapies  Pave a Way towards the Precision Treatment of Head and Neck Cancer

Georgia Zhuo Chen博士，美国埃默里大学教授

题目: Recent Advances in Anti-tumour Berberine

Paolo Lombardi博士，意大利Naxospharma公司总裁、联合创始人

题目: FL118, A Novel Anticancer Drug, for Personalized Medicine Using the Unexpected Kras Gene Status as a Biomarker

Fengzhi Li博士，美国Roswell Park 癌症研究所首席科学家，Canget BioTekpharma公司首席科学家

题目: The Development of Ingenol Disoxate for the Treatment of Actinic Keratosis and Other Non-Melanoma Skin Cancers

Thomas Hogberg博士，丹麦Mind the Byte公司高级顾问

题目: Metformin: A Drug for All Reasons - an Update on the Therapeutics Effects of Metformin

Christopher R. Triggle博士，卡塔尔威尔康奈尔医学院教授

题目: Molecular Imaging and Immunotherapy of CD248-positive Cancer

Chunsheng Li博士，美国宾夕法尼亚大学副教授

题目: The Combined Use of Camellia Sinensis (Green Tea) and Metronomic Zoledronic Acid in Intratibial Breast Cancer-Induced Osteolysis Mouse Model against Tumor Metastasis and Bone Destruction

Ke-Wang Luo博士，龙华人民医院研究教育部主任

 

专场二：新抗感染药物

题目: Antivirals for Lethal RNA Virus Pathogens

Kylie M. Wagstaff博士，澳大利亚莫纳什大学癌症靶向与核治疗实验室职业发展主管、研究员

题目: New Antifungal Agents Based on Carbazone or Carbamate Fragment

Josef Jampilek博士，斯洛伐克康明尼斯大学教授

题目: Dalbavancin – A New Lipoglycopeptide

Kimberly D. Leuthner博士，美国南内华达大学医学中心传染病临床医师

题目: ALA-PDT Combined with Antibiotics for the Treatment of Multiple Skin Abscesses Caused by Mycobacterium Fortuitum

Yang Tan博士，第三军医大学大坪医院主治医师

 

论坛9：仿制药与生物仿制药的研发

题目: Wax-Matrix Extended-Release Niacin versus Inositol Hexanicotinate in Persons with Mild to Moderate Hyperlipidemia

Joseph Keenan博士，美国明尼苏达大学家庭医学部教授

题目: Safety Aspects of Biosimilar Products

Teresa Brodniewicz博士，波兰MTZ诊疗研究中心总裁

题目: Drug Delivery Systems as Critical Success Factors for Biosimilar Products

Dirk Kreder博士，德国Anteris医药公司CEO

题目: The Effect of Selective Estrogen Receptor Down-regulator (SERD) in the Treatment of Breast Cancer

Jin Zhang博士，南京圣和药业股份有限公司业务拓展经理

论坛 10：临床试验，市场与政策

题目: Critical Statistical Issues in the Design of a Non-inferiority Clinical Trial

Wei Sun博士，美国Kyowa Kirin药物开发公司生物统计副主任

题目: How to Achieve and Optimise a Long-term Relationship with a CRO Enabling Mutual Creation of Value

Lidia Cappellina女士，意大利Chiesi集团研发外包管理主任

题目: China Medical City – An Integrated Life Science Cluster in the Heart of Asia

Xiaobo Wu先生，中国医药城国际商务发展中心副主任

题目: Implications of Continuous Glucose Monitoring in Diabetes Research and Patient Management

Yong-Fu Xiao博士，中美冠科生物技术有限公司，美国罗格斯大学研究员、教授，

题目: Handling Missing Data in Clinical Trials

Giovanni Dondi Dall’Orologio博士，意大利博洛尼亚大学教授、主任

题目: Effectiveness of Bibliographic Research from Scientific Databases

Loretta De Franceschi博士，意大利乌尔比诺大学教授

题目: Hospitalizations and Economic Analysis in Psychotic Patients with Paliperidone Palmitate Long-Acting Injection

Jesus E. Mesones博士，西班牙特拉维哈大学医院精神科主任

题目: Quality Requirements in R & D

Allen Edward Goldenthal博士，澳门大学高级质量顾问

 

论坛11：药物化学与药物发现

题目: Drug ADME Profiling -- Understanding the Practical Examples

Zack Zou博士，桑迪亚医药技术(上海)有限责任公司副总裁

题目: Should CADD be Interpreted and also Applied Differently

Thomas Hogberg博士，丹麦Mind the Byte高级顾问

题目: Chirality Determination of Organic Compounds and Chiral Drugs by Using Asymmetric Autocatalysis

Kenso Soai博士，日本东京理科大学教授

题目: Replication of L- and D-Amino Acids via Strecker Synthesis with Asymmetric Amplification and Multiplication of L- and D-Aminonitriles

Tsuneomi Kawasaki博士，日本东京理科大学教授

题目: A Novel Targeted Drug Enhancer for Liver Cancer

Shi Peng博士，北京YunHui医疗科技有限公司研发主管

题目: Overview of LH031, An Orallykinesinspindle Protein Eg5 Inhibitor for the Treatment of Cancer

Shiqun Zhang博士，广州Link Health集团总经理助理

题目: Myelination and Demyelination - A Sphingolipid Mystery

Somsankar Dasgupta博士，美国奥古斯塔大学名誉教授

题目: Identification of Thiazolidine-2,4-dione Derivatives as a Novel Class of Glutaminase Inhibitors

Shiow-Ju Lee博士，台湾国家卫生研究院生物技术与医药研究所副调研员

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